Reports of Radiotherapy and Oncology

Published by: Kowsar

Evaluation of Relationship Between Testicular Dose and Hormonal Changes After Radiotherapy in Patients With Rectal Cancer

Ainaz Sourati 1 , * , Mona Malekzadeh 1 , Mohsen Bakhshandeh 2 , Ahmad Moosavizadeh 1 and Zohre Azma 3
Authors Information
1 Radiotherapy and Oncology Department, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Medical Physics-Radiology Department, Para Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Radiation Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Reports of Radiotherapy and Oncology: January 28, 2015, 2 (1); e885
  • Published Online: January 24, 2015
  • Article Type: Research Article
  • Received: February 10, 2015
  • Revised: February 15, 2015
  • Accepted: February 25, 2015
  • DOI: 10.5812/rro.885

To Cite: Sourati A, Malekzadeh M, Bakhshandeh M, Moosavizadeh A, Azma Z. Evaluation of Relationship Between Testicular Dose and Hormonal Changes After Radiotherapy in Patients With Rectal Cancer, Rep Radiother Oncol. 2015 ; 2(1):e885. doi: 10.5812/rro.885.

Copyright © 2015, Iranian Society of Clinical Oncology.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, et al. Colorectal cancer. Lancet. 2010; 375(9719): 1030-47[DOI]
  • 2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61(2): 69-90[DOI][PubMed]
  • 3. Bruheim K, Svartberg J, Carlsen E, Dueland S, Haug E, Skovlund E, et al. Radiotherapy for rectal cancer is associated with reduced serum testosterone and increased FSH and LH. Int J Radiat Oncol Biol Phys. 2008; 70(3): 722-7[DOI][PubMed]
  • 4. Merika E, Saif MW, Katz A, Syrigos K, Morse M. Review. Colon cancer vaccines: an update. In Vivo. 2010; 24(5): 607-28[PubMed]
  • 5. Manual of clinical oncology. 2004;
  • 6. Bruheim K, Guren MG, Dahl AA, Skovlund E, Balteskard L, Carlsen E, et al. Sexual function in males after radiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys. 2010; 76(4): 1012-7[DOI][PubMed]
  • 7. Howell S, Shalet S. Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin North Am. 1998; 27(4): 927-43[PubMed]
  • 8. Dueland S, Guren MG, Olsen DR, Poulsen JP, Magne Tveit K. Radiation therapy induced changes in male sex hormone levels in rectal cancer patients. Radiother Oncol. 2003; 68(3): 249-53[PubMed]
  • 9. Ogilvy-Stuart AL, Shalet SM. Effect of radiation on the human reproductive system. Environ Health Perspect. 1993; 101 Suppl 2: 109-16[PubMed]
  • 10. Zagars GK, Pollack A. Serum testosterone levels after external beam radiation for clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 1997; 39(1): 85-9[PubMed]
  • 11. Tomic R, Bergman B, Damber JE, Littbrand B, Lofroth PO. Effects of external radiation therapy for cancer of the prostate on the serum concentrations of testosterone, follicle-stimulating hormone, luteinizing hormone and prolactin. J Urol. 1983; 130(2): 287-9[PubMed]
  • 12. Inomata A, Matsumoto H, Horii I. Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 18). Comparative 4 and 2 weeks oral repeated dosing studies on male reproductive organs in rats treated with 5-fluorouracil. J Toxicol Sci. 2000; 25 Spec No: 179-86[PubMed]
  • 13. Takizawa S, Horii I. Endocrinological assessment of toxic effects on the male reproductive system in rats treated with 5-fluorouracil for 2 or 4 weeks. J Toxicol Sci. 2002; 27(1): 49-56[PubMed]
  • 14. Hermann RM, Henkel K, Christiansen H, Vorwerk H, Hille A, Hess CF, et al. Testicular dose and hormonal changes after radiotherapy of rectal cancer. Radiother Oncol. 2005; 75(1): 83-8[DOI][PubMed]
  • 15. Mazonakis M, Damilakis J, Varveris H, Gourtsouiannis N. Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer. Oncol Rep. 2006; 15(3): 729-33[PubMed]
  • 16. Budgell GJ, Cowan RA, Hounsell AR. Prediction of scattered dose to the testes in abdominopelvic radiotherapy. Clin Oncol (R Coll Radiol). 2001; 13(2): 120-5[PubMed]
  • 17. Yoon FH, Perera F, Fisher B, Stitt L. Alterations in hormone levels after adjuvant chemoradiation in male rectal cancer patients. Int J Radiat Oncol Biol Phys. 2009; 74(4): 1186-90[DOI][PubMed]
  • 18. Joos H, Sedlmayer F, Gomahr A, Rahim HB, Frick J, Kogelnik HD, et al. Endocrine profiles after radiotherapy in stage I seminoma: impact of two different radiation treatment modalities. Radiother Oncol. 1997; 43(2): 159-62[PubMed]
  • 19. Hennies S, Wolff HA, Jung K, Rave-Frank M, Gaedcke J, Ghadimi M, et al. Testicular radiation dose after multimodal curative therapy for locally advanced rectal cancer. Influence on hormone levels, quality of life, and sexual functioning. Strahlenther Onkol. 2012; 188(10): 926-32[DOI][PubMed]
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