Reports of Radiotherapy and Oncology

Published by: Kowsar

Therapeutic Potential of Curcumin in Breast Cancer: From Basic Research to Clinical Applications

Milad Hashemzehi 1 , Soodabeh ShahidSales 2 , Seyed Mahdi Hassanian 3 , 4 , Mona Joudi Mashhad 2 , Amir Avan 4 , 5 , * and Majid Khazaei 1 , *
Authors Information
1 Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
4 Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, IR Iran
5 Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
Corresponding Authors:
Article information
  • Reports of Radiotherapy and Oncology: December 2015, 2 (4); e59228
  • Published Online: December 31, 2015
  • Article Type: Review Article
  • Received: September 30, 2015
  • Accepted: November 28, 2015
  • DOI: 10.5812/rro.59228

To Cite: Hashemzehi M, ShahidSales S, Hassanian S M, Joudi Mashhad M, Avan A, et al. Therapeutic Potential of Curcumin in Breast Cancer: From Basic Research to Clinical Applications, Rep Radiother Oncol. 2015 ; 2(4):e59228. doi: 10.5812/rro.59228.

Copyright © 2015, Reports of Radiotherapy and Oncology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Antioxidant Effects
3. Antiinflammatory Effects
4. Anticancer Effects
5. Anticancer Effects on Breast Cancer
6. Conclusions
  • 1. Stewart SL, King JB, Thompson TD, Friedman C, Wingo PA. Cancer mortality surveillance--United States, 1990-2000. MMWR Surveill Summ. 2004; 53(3): 1-108[PubMed]
  • 2. Dumitrescu RG, Cotarla I. Understanding breast cancer risk -- where do we stand in 2005? J Cell Mol Med. 2005; 9(1): 208-21[PubMed]
  • 3. Montazeri A. Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007. J Exp Clin Cancer Res. 2008; 27: 32[DOI][PubMed]
  • 4. Akram M, Uddin S, Ahmed A, Usmanghani K, Hannan A, Mohiuddin E, et al. Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol. 2010; 55(2): 65-70
  • 5. Li S, Yuan W, Deng G, Wang P, Yang P, Aggarwal BB. Chemical composition and product quality control of turmeric (Curcuma longa L.). 2011;
  • 6. Barros L, Ferreira MJ, Queiros B, Ferreira ICFR, Baptista P. Total phenols, ascorbic acid, β-carotene and lycopene in Portuguese wild edible mushrooms and their antioxidant activities. Food Chem. 2007; 103(2): 413-9[DOI]
  • 7. Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 1990; 186: 1-85[PubMed]
  • 8. Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 1991; 51(3): 813-9[PubMed]
  • 9. Skrzypczak-Jankun E, McCabe NP, Selman SH, Jankun J. Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence. Int J Mol Med. 2000; 6(5): 521-6[PubMed]
  • 10. Priyadarsini KI, Maity DK, Naik GH, Kumar MS, Unnikrishnan MK, Satav JG, et al. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic Biol Med. 2003; 35(5): 475-84[PubMed]
  • 11. Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett. 1995; 94(1): 79-83[PubMed]
  • 12. Su CC, Lin JG, Li TM, Chung JG, Yang JS, Ip SW, et al. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res. 2006; 26(6B): 4379-89[PubMed]
  • 13. Sharma RA. Translational medicine: targetting cyclo-oxygenase isozymes to prevent cancer. QJM. 2002; 95(5): 267-73[PubMed]
  • 14. Surh YJ, Chun KS. Cancer chemopreventive effects of curcumin. Adv Exp Med Biol. 2007; 595: 149-72[DOI][PubMed]
  • 15. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res. 2001; 480-481: 243-68[PubMed]
  • 16. Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, et al. Biological and therapeutic activities, and anticancer properties of curcumin. Exp Ther Med. 2015; 10(5): 1615-23[DOI][PubMed]
  • 17. Li Y, Zhang S, Geng JX, Hu XY. Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C. Asian Pac J Cancer Prev. 2013; 14(8): 4599-602[PubMed]
  • 18. Yadav R, Jee B, Awasthi SK. Curcumin Suppresses the Production of Pro-inflammatory Cytokine Interleukin-18 in Lipopolysaccharide Stimulated Murine Macrophage-Like Cells. Indian J Clin Biochem. 2015; 30(1): 109-12[DOI][PubMed]
  • 19. Yang CL, Liu YY, Ma YG, Xue YX, Liu DG, Ren Y, et al. Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PLoS One. 2012; 7(5)[DOI][PubMed]
  • 20. Shafiee M, Mohamadzade E, ShahidSales S, Khakpouri S, Maftouh M, Parizadeh SA, et al. Current Status and Perspectives Regarding the Therapeutic Potential of Targeting EGFR Pathway by Curcumin in Lung Cancer. Curr Pharm Des. 2017; 23(13): 2002-8[DOI][PubMed]
  • 21. Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer. 2005; 104(6): 1322-31[DOI][PubMed]
  • 22. Bao B, Ali S, Banerjee S, Wang Z, Logna F, Azmi AS, et al. Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Cancer Res. 2012; 72(1): 335-45[DOI][PubMed]
  • 23. Bimonte S, Barbieri A, Palma G, Luciano A, Rea D, Arra C. Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer. BioMed Res Int. 2013; 2013
  • 24. Jutooru I, Chadalapaka G, Lei P, Safe S. Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. J Biol Chem. 2010; 285(33): 25332-44[DOI][PubMed]
  • 25. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res. 2008; 14(14): 4491-9
  • 26. Epelbaum R, Schaffer M, Vizel B, Badmaev V, Bar-Sela G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer. 2010; 62(8): 1137-41[DOI][PubMed]
  • 27. Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, et al. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol. 2011; 68(1): 157-64[DOI][PubMed]
  • 28. Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance Sharma. 2010;
  • 29. Hosseini M, Hassanian SM, Mohammadzadeh E, ShahidSales S, Maftouh M, Fayazbakhsh H, et al. Therapeutic Potential of Curcumin in Treatment of Pancreatic Cancer: Current Status and Future Perspectives. J Cell Biochem. 2017; 118(7): 1634-8[DOI][PubMed]
  • 30. Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate. 2001; 47(4): 293-303[DOI][PubMed]
  • 31. Hong JH, Ahn KS, Bae E, Jeon SS, Choi HY. The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo. Prostate Cancer Prostatic Dis. 2006; 9(2): 147-52[DOI][PubMed]
  • 32. Cui SX, Qu XJ, Xie YY, Zhou L, Nakata M, Makuuchi M, et al. Curcumin inhibits telomerase activity in human cancer cell lines. Int J Mol Med. 2006; 18(2): 227-31[PubMed]
  • 33. Tu SP, Jin H, Shi JD, Zhu LM, Suo Y, Lu G, et al. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev Res (Phila). 2012; 5(2): 205-15[DOI][PubMed]
  • 34. Carroll RE, Benya RV, Turgeon DK, Vareed S, Neuman M, Rodriguez L, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila). 2011; 4(3): 354-64[DOI][PubMed]
  • 35. Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res. 2001; 7(7): 1894-900[PubMed]
  • 36. Ghalaut VS, Sangwan L, Dahiya K, Ghalaut PS, Dhankhar R, Saharan R. Effect of imatinib therapy with and without turmeric powder on nitric oxide levels in chronic myeloid leukemia. J Oncol Pharm Pract. 2012; 18(2): 186-90[DOI][PubMed]
  • 37. Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, et al. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 2005; 11(20): 7490-8[DOI][PubMed]
  • 38. Ramachandran C, Rodriguez S, Ramachandran R, Raveendran Nair PK, Fonseca H, Khatib Z, et al. Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines. Anticancer Res. 2005; 25(5): 3293-302[PubMed]
  • 39. Prasad CP, Rath G, Mathur S, Bhatnagar D, Ralhan R. Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/beta-catenin signaling. Chem Biol Interact. 2009; 181(2): 263-71[DOI][PubMed]
  • 40. Lv ZD, Liu XP, Zhao WJ, Dong Q, Li FN, Wang HB, et al. Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo. Int J Clin Exp Pathol. 2014; 7(6): 2818-24[PubMed]
  • 41. Choudhuri T, Pal S, Agwarwal ML, Das T, Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 2002; 512(1-3): 334-40[PubMed]
  • 42. Holy JM. Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells. Mutat Res. 2002; 518(1): 71-84[PubMed]
  • 43. DeNardo DG, Coussens LM. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res. 2007; 9(4): 212[DOI][PubMed]
  • 44. Bachmeier BE, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, Hohneke C, et al. Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis. 2008; 29(4): 779-89[DOI][PubMed]
  • 45. Kronski E, Fiori ME, Barbieri O, Astigiano S, Mirisola V, Killian PH, et al. miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2. Mol Oncol. 2014; 8(3): 581-95[DOI][PubMed]
  • 46. Zong H, Wang F, Fan QX, Wang LX. Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways. Mol Biol Rep. 2012; 39(4): 4803-8[DOI][PubMed]
  • 47. Liu Q, Loo WT, Sze SC, Tong Y. Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription. Phytomedicine. 2009; 16(10): 916-22[DOI][PubMed]
  • 48. Kim HI, Huang H, Cheepala S, Huang S, Chung J. Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion. Cancer Prev Res (Phila). 2008; 1(5): 385-91[DOI][PubMed]
  • 49. Mo N, Li ZQ, Li J, Cao YD. Curcumin inhibits TGF-beta1-induced MMP-9 and invasion through ERK and Smad signaling in breast cancer MDA- MB-231 cells. Asian Pac J Cancer Prev. 2012; 13(11): 5709-14[PubMed]
  • 50. Kim JM, Noh EM, Kwon KB, Kim JS, You YO, Hwang JK, et al. Curcumin suppresses the TPA-induced invasion through inhibition of PKCalpha-dependent MMP-expression in MCF-7 human breast cancer cells. Phytomedicine. 2012; 19(12): 1085-92[DOI][PubMed]
  • 51. Nasiri M, Zarghami N, Koshki KN, Mollazadeh M, Moghaddam MP, Yamchi MR, et al. Curcumin and silibinin inhibit telomerase expression in T47D human breast cancer cells. Asian Pac J Cancer Prev. 2013; 14(6): 3449-53[PubMed]
  • 52. Ramachandran C, Fonseca HB, Jhabvala P, Escalon EA, Melnick SJ. Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett. 2002; 184(1): 1-6[PubMed]
  • 53. Chen B, Zhang Y, Wang Y, Rao J, Jiang X, Xu Z. Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression. J Steroid Biochem Mol Biol. 2014; 143: 11-8[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments