Reports of Radiotherapy and Oncology

Published by: Kowsar

Hippocampal Sparing Post-Operative Radiation Therapy and Its Impact on Memory Function in Newly Diagnosed High Grade Glioma Patients

N Santhosh 1 , Poojar Sridhar 1 , * , K P R Pramod 1 and Rahul Loni 1
Authors Information
1 Department of Radiation Oncology, Kidwai Cancer Institute, Bangalore, India
Article information
  • Reports of Radiotherapy and Oncology: March 2016, 3 (1); e57084
  • Published Online: March 31, 2016
  • Article Type: Research Article
  • Received: January 12, 2016
  • Revised: February 3, 2016
  • Accepted: March 1, 2016
  • DOI: 10.5812/rro.57084

To Cite: Santhosh N, Sridhar P, Pramod K P R, Loni R. Hippocampal Sparing Post-Operative Radiation Therapy and Its Impact on Memory Function in Newly Diagnosed High Grade Glioma Patients, Rep Radiother Oncol. 2016 ; 3(1):e57084. doi: 10.5812/rro.57084.

Copyright © 2016, Reports of Radiotherapy and Oncology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, et al. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012. Neuro Oncol. 2015;17 Suppl 4:iv1-iv62. doi: 10.1093/neuonc/nov189. [PubMed: 26511214].
  • 2. Gondi V, Tome WA, Mehta MP. Why avoid the hippocampus? A comprehensive review. Radiother Oncol. 2010;97(3):370-6. doi: 10.1016/j.radonc.2010.09.013. [PubMed: 20970214].
  • 3. Pinkham MB, Bertrand KC, Olson S, Zarate D, Oram J, Pullar A, et al. Hippocampal-sparing radiotherapy: the new standard of care for World Health Organization grade II and III gliomas? J Clin Neurosci. 2014;21(1):86-90. doi: 10.1016/j.jocn.2013.04.005. [PubMed: 24090519].
  • 4. Vinai Gondi V, Wolfgang A T, Howard A. R , Minesh P. M . Hippocampal Contouring: A Contouring Atlas for RTOG0933. 2013. Available from:
  • 5. Pershad D, Wig NN. Reliability and validity of a new battery of memory tests. Ind J Psychiatry. 1978;20.
  • 6. Gunderson LL, Tepper JE. Clinical Radiation Oncology. 4 ed. 2015.
  • 7. Kempermann G, Jessberger S, Steiner B, Kronenberg G. Milestones of neuronal development in the adult hippocampus. Trends Neurosci. 2004;27(8):447-52. doi: 10.1016/j.tins.2004.05.013. [PubMed: 15271491].
  • 8. Marsh JC, Godbole R, Diaz AZ, Gielda BT, Turian JV. Sparing of the hippocampus, limbic circuit and neural stem cell compartment during partial brain radiotherapy for glioma: a dosimetric feasibility study. J Med Imaging Radiat Oncol. 2011;55(4):442-9. doi: 10.1111/j.1754-9485.2011.02282.x. [PubMed: 21843181].

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