Reports of Radiotherapy and Oncology

Published by: Kowsar

Pain Management in Mesothelioma

Nicholas MacLeod 1 , 2 , * , Pal Klepstad 3 , 4 , Marie Fallon 1 , 5 and Barry Laird 1 , 2 , 5
Authors Information
1 Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK
2 Beatson West of Scotland Cancer Centre, Glasgow, UK
3 Department of Anaesthesiology and Emergency Medicine, St Olavs University Hospital, Trondheim, Norway
4 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
5 Western General Hospital, Edinburgh, UK
Article information
  • Reports of Radiotherapy and Oncology: September 2015, 2 (3); e3835
  • Published Online: September 28, 2015
  • Article Type: Case Report
  • Received: August 13, 2015
  • Accepted: September 20, 2016
  • DOI: 10.17795/rro-3835

To Cite: MacLeod N, Klepstad P, Fallon M, Laird B. Pain Management in Mesothelioma, Rep Radiother Oncol. 2015 ; 2(3):e3835. doi: 10.17795/rro-3835.

Copyright © 2016, Iranian Society of Clinical Oncology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Davidson B. New diagnostic and molecular characteristics of malignant mesothelioma. Ultrastruct Pathol. 2008; 32(6): 227-40[DOI][PubMed]
  • 2. Muers MF, Stephens RJ, Fisher P. Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial. Lancet. 2008; 371: 1685-94[DOI]
  • 3. Jackson MB, Pounder D, Price C, Matthews AW, Neville E. Percutaneous cervical cordotomy for the control of pain in patients with pleural mesothelioma. Thorax. 1999; 54(3): 238-41[PubMed]
  • 4. Salminen EK, Silvoniemi M, Syrjanen K, Kaasa S, Kloke M, Klepstad P. Opioids in pain management of mesothelioma and lung cancer patients. Acta Oncol. 2013; 52(1): 30-7[DOI][PubMed]
  • 5. Geneva W. Cancer pain relief 1996;
  • 6. Caraceni A, Hanks G, Kaasa S. Use of opioid analgesics in the treatment of cancer pain: evidenced-based recommendation from the EAPC. Lancet Oncol. 2012; 13: 58-68[DOI]
  • 7. Donnelly S, Davis MP, Walsh D, Naughton M, World Health O. Morphine in cancer pain management: a practical guide. Support Care Cancer. 2002; 10(1): 13-35[PubMed]
  • 8. Klepstad P, Kaasa S, Jystad A, Hval B, Borchgrevink PC. Immediate- or sustained-release morphine for dose-finding during start of morphine to cancer patients: a randomised, double-blind trial. Pain. 2003; 101: 193-8[DOI]
  • 9. Gilron I, Bailey JM, Tu D, Holden RR, Weaver DF, Houlden RL. Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med. 2005; 352(13): 1324-34[DOI][PubMed]
  • 10. Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst Rev. 2007; [DOI]
  • 11. Preskorn SH, Irwin HA. Toxicity of tricyclic antidepressants--kinetics, mechanism, intervention: a review. J Clin Psychiatry. 1982; 43(4): 151-6[PubMed]
  • 12. Backonja MM. Anticonvulsants (antineuropathics) for neuropathic pain syndromes. Clin J Pain. 2000; 16(2 Suppl)-72[PubMed]
  • 13. Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain. 2007; 132(3): 237-51[DOI][PubMed]
  • 14. Freynhagen R, Strojek K, Griesing T, Whalen E, Balkenohl M. Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens. Pain. 2005; 115(3): 254-63[DOI][PubMed]
  • 15. Mishra S, Bhatnagar S, Goyal GN, Rana SP, Upadhya SP. A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study. Am J Hosp Palliat Care. 2012; 29(3): 177-82[DOI][PubMed]
  • 16. Bell RF, Eccleston C, Kalso E. Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review. J Pain Symptom Manage. 2003; 26(3): 867-75[PubMed]
  • 17. Fleming JA, O'Connor BD. Use of lidocaine patches for neuropathic pain in a comprehensive cancer centre. Pain Res Manag. 2009; 14(5): 381-8[PubMed]
  • 18. Jones VM, Moore KA, Peterson DM. Capsaicin 8% topical patch (Qutenza)--a review of the evidence. J Pain Palliat Care Pharmacother. 2011; 25(1): 32-41[DOI][PubMed]
  • 19. Scherpereel A, Astoul P, Baas P, Berghmans T, Clayson H, de Vuyst P, et al. Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir J. 2010; 35(3): 479-95[DOI][PubMed]
  • 20. Bissett D, Macbeth FR, Cram I. The role of palliative radiotherapy in malignant mesothelioma. Clin Oncol (R Coll Radiol). 1991; 3(6): 315-7[PubMed]
  • 21. Jenkins P, Milliner R, Salmon C. Re-evaluating the role of palliative radiotherapy in malignant pleural mesothelioma. Eur J Cancer. 2011; 47(14): 2143-9[DOI][PubMed]
  • 22. van Meerbeeck JP, Gaafar R, Manegold C, Van Klaveren RJ, Van Marck EA, Vincent M, et al. Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. J Clin Oncol. 2005; 23(28): 6881-9[DOI][PubMed]
  • 23. Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003; 21(14): 2636-44[DOI][PubMed]
  • 24. Bottomley A, Gaafar R, Manegold C, Burgers S, Coens C, Legrand C, et al. Short-term treatment-related symptoms and quality of life: results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an EORTC Lung-Cancer Group and National Cancer Institute, Canada, Intergroup Study. J Clin Oncol. 2006; 24(9): 1435-42[DOI][PubMed]
  • 25. Chapman A, Mulrennan S, Ladd B, Muers MF. Population based epidemiology and prognosis of mesothelioma in Leeds, UK. Thorax. 2008; 63(5): 435-9[DOI][PubMed]
  • 26. Christo PJ, Mazloomdoost D. Interventional pain treatments for cancer pain. Ann N Y Acad Sci. 2008; 1138: 299-328[DOI][PubMed]
  • 27. Amesbury B, O'Riordan J, Dolin S. The use of interpleural analgesia using bupivacaine for pain relief in advanced cancer. Palliat Med. 1999; 13(2): 153-8[PubMed]
  • 28. Kanpolat Y, Savas A, Ucar T, Torun F. CT-guided percutaneous selective cordotomy for treatment of intractable pain in patients with malignant pleural mesothelioma. Acta Neurochir (Wien). 2002; 144(6): 595-9[DOI][PubMed]
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